diff --git a/CMake/vtkModuleWrapPython.cmake b/CMake/vtkModuleWrapPython.cmake
index fe7401f5154f9f25205874c63665ce44c23c1b6d..56fffbed765e87055c3eae57b539de6e7c8d5410 100644
--- a/CMake/vtkModuleWrapPython.cmake
+++ b/CMake/vtkModuleWrapPython.cmake
@@ -456,8 +456,13 @@ extern PyObject* PyInit_${_vtk_python_library_name}();
       # configuration, whether it is a debug build. If it is, add the postfix
       # (regardless of VTK's build type). Otherwise, no postfix.
       if (_vtk_python_USE_DEBUG_SUFFIX)
+        if (_vtk_python_REPLACE_DEBUG_SUFFIX)
+          set(_vtk_python_append_flag)
+        else ()
+          set(_vtk_python_append_flag APPEND_STRING)
+        endif ()
         set_property(TARGET "${name}"
-          APPEND_STRING
+          ${_vtk_python_append_flag}
           PROPERTY
             DEBUG_POSTFIX "_d")
       endif ()
@@ -554,6 +559,7 @@ vtk_module_wrap_python(
   [PYTHON_PACKAGE <package>]
   [SOABI <soabi>]
   [USE_DEBUG_SUFFIX <ON|OFF>]
+  [REPLACE_DEBUG_SUFFIX <ON|OFF>]
 
   [INSTALL_EXPORT <export>]
   [COMPONENT <component>])
@@ -608,6 +614,8 @@ vtk_module_wrap_python(
   * `USE_DEBUG_SUFFIX` (Defaults to `OFF`): If `ON`, Windows modules will have
     a `_d` suffix appended to the module name. This is intended for use with
     debug Python builds.
+  * `REPLACE_DEBUG_SUFFIX` (Defaults to `OFF`): If `ON`, any project-wide debug
+    suffix will be replaced with the local debug suffix (if enabled).
   * `INSTALL_EXPORT`: If provided, static installs will add the installed
     libraries to the provided export set.
   * `COMPONENT`: Defaults to `python`. All install rules created by this
@@ -616,7 +624,7 @@ vtk_module_wrap_python(
 function (vtk_module_wrap_python)
   cmake_parse_arguments(PARSE_ARGV 0 _vtk_python
     ""
-    "MODULE_DESTINATION;STATIC_MODULE_DESTINATION;LIBRARY_DESTINATION;PYTHON_PACKAGE;BUILD_STATIC;INSTALL_HEADERS;INSTALL_EXPORT;TARGET_SPECIFIC_COMPONENTS;TARGET;COMPONENT;WRAPPED_MODULES;CMAKE_DESTINATION;SOABI;USE_DEBUG_SUFFIX;UTILITY_TARGET;BUILD_PYI_FILES"
+    "MODULE_DESTINATION;STATIC_MODULE_DESTINATION;LIBRARY_DESTINATION;PYTHON_PACKAGE;BUILD_STATIC;INSTALL_HEADERS;INSTALL_EXPORT;TARGET_SPECIFIC_COMPONENTS;TARGET;COMPONENT;WRAPPED_MODULES;CMAKE_DESTINATION;SOABI;USE_DEBUG_SUFFIX;REPLACE_DEBUG_SUFFIX;UTILITY_TARGET;BUILD_PYI_FILES"
     "DEPENDS;MODULES")
 
   if (_vtk_python_UNPARSED_ARGUMENTS)
@@ -660,6 +668,10 @@ function (vtk_module_wrap_python)
     set(_vtk_python_USE_DEBUG_SUFFIX OFF)
   endif ()
 
+  if (NOT DEFINED _vtk_python_REPLACE_DEBUG_SUFFIX)
+    set(_vtk_python_REPLACE_DEBUG_SUFFIX OFF)
+  endif ()
+
   if (_vtk_python_SOABI)
     get_property(_vtk_python_is_multi_config GLOBAL
       PROPERTY GENERATOR_IS_MULTI_CONFIG)
diff --git a/CMakeLists.txt b/CMakeLists.txt
index e8d620a0a8a1fc520bac8ca45d77467a53e4ba2f..45a35bd48823f2614b0011e7baf9f4c0cf5f8138 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -492,6 +492,9 @@ if (VTK_WRAP_PYTHON)
   cmake_dependent_option(VTK_WINDOWS_PYTHON_DEBUGGABLE "Append `_d` to Python module names" OFF
     "WIN32;VTK_WRAP_PYTHON" OFF)
   mark_as_advanced(VTK_WINDOWS_PYTHON_DEBUGGABLE)
+  cmake_dependent_option(VTK_WINDOWS_PYTHON_DEBUGGABLE_REPLACE_SUFFIX "Replace any other debug suffix for Python module names" OFF
+    "VTK_WINDOWS_PYTHON_DEBUGGABLE" OFF)
+  mark_as_advanced(VTK_WINDOWS_PYTHON_DEBUGGABLE_REPLACE_SUFFIX)
   cmake_dependent_option(VTK_BUILD_PYI_FILES "Build `.pyi` files for VTK's Python modules" OFF
     "VTK_WRAP_PYTHON" OFF)
   mark_as_advanced(VTK_BUILD_PYI_FILES)
@@ -514,6 +517,7 @@ if (VTK_WRAP_PYTHON)
     BUILD_PYI_FILES     "${VTK_BUILD_PYI_FILES}"
     SOABI               "${vtk_soabi}"
     USE_DEBUG_SUFFIX    "${VTK_WINDOWS_PYTHON_DEBUGGABLE}"
+    REPLACE_DEBUG_SUFFIX "${VTK_WINDOWS_PYTHON_DEBUGGABLE_REPLACE_SUFFIX}"
     UTILITY_TARGET      "VTK::vtkbuild"
     WRAPPED_MODULES vtk_python_wrapped_modules
     TARGET_SPECIFIC_COMPONENTS "${VTK_TARGET_SPECIFIC_COMPONENTS}"
diff --git a/Documentation/dev/build.md b/Documentation/dev/build.md
index bf8b108fa9f37eb5f5af93809135756140784083..2cfb3aee29f574e982b3dc3578e7d5c25331f98e 100644
--- a/Documentation/dev/build.md
+++ b/Documentation/dev/build.md
@@ -282,6 +282,8 @@ More advanced options:
     "${MPIEXEC_EXECUTABLE}" "${MPIEXEC_NUMPROC_FLAG}" "1" ${MPIEXEC_PREFLAGS}
   * `VTK_WINDOWS_PYTHON_DEBUGGABLE` (default `OFF`): Set to `ON` if using a
     debug build of Python.
+  * `VTK_WINDOWS_PYTHON_DEBUGGABLE_REPLACE_SUFFIX` (default `OFF`): Set to `ON`
+    to use just a `_d` suffix for Python modules.
   * `VTK_BUILD_PYI_FILES` (default `OFF`): Set to `ON` to build `.pyi` type
     hint files for VTK's Python interfaces.
   * `VTK_DLL_PATHS` (default `""` or `VTK_DLL_PATHS` from the environment): If