For clang, this allows passing -target <triple> to the compiler, and
for qcc, -V<arch> using toolchain files containing something like

 set(triple arm-linux-gnueabihf)
 set(CMAKE_C_COMPILER "/usr/bin/clang")
 set(CMAKE_C_COMPILER_TARGET ${triple})
 set(CMAKE_CXX_COMPILER "/usr/bin/clang++")
 set(CMAKE_CXX_COMPILER_TARGET ${triple})

or

 set(arch gcc_ntoarmv7le)
 set(CMAKE_C_COMPILER /opt/qnx650/host/linux/x86/usr/bin/qcc)
 set(CMAKE_C_COMPILER_TARGET ${arch})
 set(CMAKE_CXX_COMPILER /opt/qnx650/host/linux/x86/usr/bin/QCC)
 set(CMAKE_CXX_COMPILER_TARGET ${arch})

Both clang and qcc are inherently cross compiler( driver)s.